For moderate to severe acne, you may need oral antibiotics to reduce bacteria and fight inflammation. Usually, the first choice for treating acne is tetracycline — such as minocycline or doxycycline — or a macrolide. Antibiotics work by controlling the bacterial infection that contributes to … the lumps are larger, deeper and may appear as nodules and cysts.
Persistent or severe acne responds best to oral acne medications. You have plenty of options beyond isotretinoin (Accutane). Which medications work best for different types of acne? … a macrolide, have often been used to treat moderate to severe inflammatory acne.